Long-Read Precision for Chromosome-End Insight

Wasatch BioLabs’ Telomere Sequencing (Teloseq) service provides direct, molecule-level measurement of telomere length and subtelomeric structure from native DNA. Powered by Oxford Nanopore long-read sequencing, Teloseq integrates global and arm-specific telomere length, subtelomeric methylation (DMRs), and structural variant (SV) analysis into a single, scalable assay. Teloseq captures the full landscape of telomere physiology, enabling the use of biobanked or fresh tissue-derived DNA for discovery, translational, and clinical applications.

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Beyond Global Telomere Length: The Resolution That Matters

Traditional assays average telomere features across chromosomes, obscuring the arm-specific differences that may hold key biological and clinical insights. Teloseq resolves these features with full chromosome-arm and subtelomeric context, uncovering patterns that may clarify how telomere dynamics influence aging and disease.

Subtelomeric Context:

Measure adjacent epigenomic and variant structures missed by traditional assays.

Native DNA Input:

Profile native telomeric structures directly from extracted DNA, no live cell handling.

Translational Scalability:

Seamlessly scale from biobanked samples to prospective clinical cohorts.

Attribute

Legacy Assays (Flow-FISH, qPCR, TRF)

WBL Teloseq (Long-Read)

Input Type

Requires Live, Viable Cells

Uses Extracted Genomic DNA Only

Output Type

Global Averages Or Cell-Type Bins

Per-Arm Distributions With Subtelomeric Context

Resolution

No Locus-Level Specificity

Single-Molecule Reads Mapped To Chromosome Arms

Logistics

Tight Shipping And Viability Constraints

DNA-Only Input Allows Stable, Simple Shipping

Biological Insight

Struggles With Subtelomeric Coverage

Detects Adjacent DMRs And SVs For Mechanistic Context

Scalability

Limited To Fresh Samples

Compatible With Biobanked Or Stored DNA

Throughput

Low And Sample-Limited

Multiplexed, High-Throughput Long-Read Platform

Long-Read Teloseq Outperforms Legacy Telomere Methods

Legacy telomere assays average signals and often miss chromosome-arm variation, obscuring biologically important differences. WBL’s long-read Teloseq measures native telomere length and subtelomeric structure molecule-by-molecule, delivering the resolution required for accurate characterization and translational insight.

Sample Input:
5 µg high-molecular-weight DNA (no live-cell requirement).
Library Prep & Sequencing:
ONT Teloseq workflow with barcoded ligation.
Data Processing:
Read alignment, per-arm TL quantification, DMR/SV annotation.
QC Reporting:
Arm-level TL distributions, subtelomeric context visualizations,

The Process: From Extraction to Arm-Resolved Results

A single Teloseq run replaces multiple legacy workflows, providing per-arm TL, subtelomeric methylation, and variant analysis from a single DNA extraction.

Parameter

Specifications

DNA Input

5 µg High Molecular Weight Genomic DNA

Custom Coverage

Minimum 10 Reads Per Arm, Coverage Increases With Lower Multiplexing

Replicate Precision

Technical Replicate Concordance (r ≥0.95)

Turnaround Time

Standard 7–10 Business Days

Deliverables

Comprehensive TL + DMR/SV Report, Per-Arm Summary Plots

Support

Dedicated Bioinformatics Team & Validation Consultation

Heading: More Than a Sequencing Service. Your Translational Partner.

Wasatch BioLabs combines native long-read sequencing, advanced subtelomeric analytics, and validation-ready workflows to support telomere research from discovery through translational development.

Long-Read Workflows

[Service]

Tailored long-read sequencing protocols optimized for high-molecular-weight DNA to resolve per-arm telomere and subtelomeric features.

Custom Bioinformatics

[Service]

Specialized long-read bioinformatics pipelines designed to detect subtelomeric DMRs and structural variants with high accuracy.

Fit-for-Purpose Validation

[Service]

Validation frameworks designed to scale seamlessly from RUO discovery studies to regulated translational and clinical implementation.

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telomere sequencing

Long-Read Precision for Chromosome-End Insight

Beyond Global Telomere Length: The Resolution That Matters

Subtelomeric Context:

Native DNA Input:

Translational Scalability:

Attribute

Legacy Assays (Flow-FISH, qPCR, TRF)

WBL Teloseq (Long-Read)

Long-Read Teloseq Outperforms Legacy Telomere Methods

The Process: From Extraction to Arm-Resolved Results

Parameter

Specifications

DNA Input

5 µg High Molecular Weight Genomic DNA

Custom Coverage

Minimum 10 Reads Per Arm, Coverage Increases With Lower Multiplexing

Replicate Precision

Technical Replicate Concordance (r ≥0.95)

Turnaround Time

Standard 7–10 Business Days

Deliverables

Comprehensive TL + DMR/SV Report, Per-Arm Summary Plots

Support

Dedicated Bioinformatics Team & Validation Consultation

Heading: More Than a Sequencing Service. Your Translational Partner.

Long-Read Workflows

[Service]

Custom Bioinformatics

[Service]

Fit-for-Purpose Validation

[Service]

Unlock Arm-Resolved Insights with Teloseq

Teloseq provides precise, contextualized telomere profiling from native DNA, helping researchers and clinicians detect the signals that global averages miss.